MECHANISM OF CLOT::
Mechanism of clotting thus appears to be simple but there is lot of complexity involved there are thirteen factors which have been identified that take part in the process of clotting these have been numbered in the order of their discovery as follows
Factor1:fibrinogen
Factor2: prothrombin
Factor3: thromboplastin
Factor4: calcium
Factor5: Accelerator globulin or proaccelerin or labile factor
Factor6: Accelerin
Factor7: proconvertin or stable factor
Factor8: platelet co factor A or antihaemophilic factor AHF or antihaemophilic globulin AHG
Factor9: platelet co-factor-2 or plasma thromboplastin component PTC or christmas factor
Factor10: stuart factor
Factor11: plasma thromboplastin antecedent (PTA)
Factor12: surface factor or hageman factor
Factor13: Fibrin stabilising factor or laki lorand factor(LLF)
The most complicated step in the process of clotting is the process of the activation of prothrombin there are two separate but related pathways involved in it they are (a) Extrinsic system (b) intrinsic system
whenever there is an injury blood is shed and it comes in contact with a damaged or changed surface this altered surface behaves for the blood as a foreign material and as a result a series of factor (see below) are activated in a sequence finally causing the activation of prothrombin this is intrinsic system of activation
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