Fibrinolysis:
Blood clot on long standing if not sterile starts dissolving this is due to proteolytic enzyme called plasmin the fibrinolysis in the blood is prevented by antiplasmin
Factors hastening clotting :
1. Heat: Warmth hastens all biochemical reaction involved in clotting of blood
2. Pressure: pressure injures platelets and liberates thromboplastin to hasten clotting
3. Wet surface: water wettable surfaces produce friction to injure platelets thus liberating thromboplastin which accelerates clotting
4. Stirring: Stirring or adding foreign bodies also accelarate clotting by fibrin formation
5. Thromboplastin : adding of thromboplastin helps to liberate thrombin which accelerates coagulation
6. Thrombin : addition of thrombin also accelerates the clotting of blood
7. Vitamin: vitamin K orally or per injection raises the prothrombin level of the blood thereby accelerating coagulation
8. Ionic calcium : calcium aids coagulation if there is a deficiency of ionic calcium
9. Adrenaline: Adrenaline injection has haemostatic action on capillaries and thus it checks bleeding it is as such not a real blood coagulation accelerator it may increase bleeding by raising blood pressure it can be used locally
10.Lipids: Lipid coagulation is a new research increasing the neutral fat and phospholipid concentration in the blood aids clotting by fibrin formation but this has a risk of thrombosis and atherosclerosis to some extent
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