Disorders Related to platelets and clotting :
purpura or thrombocytopenia::
It is a disease in which the platelet count is decreased it results in petechial haemorrhages which undergo colour changes leaving a pigment at the end clotting time is normal but bleeding time increases and clot refuses to retract it may prove serious because of the danger of internal haemorrhages
Haemophilia:
It is a disease in which because of lack of clotting of blood with minor injuries the bleeding continues unstopped this is a serious disease it is due to absence of factor 8 (antihaemophilic factor) haemophilics show normal platelet count this serious disease occurs in man but it is transmitted genetically through woman woman themselves carry the genes but do not suffer from the disease
Thrombosis:
Thrombosis is intravascular clotting of the blood slowed down circulation atherosclerosis causing narrowness of lumen of blood vessels and damage to the intima (inner walls) of the blood vessels break the platelets and finally fibrin threads are formed and a blood clot results thrombus formation starts with clotting of blood in the vessels but later RBCs pile up there at the site of clot and a jelly like mass is formed which may get elongated along the lumen of the vessel thrombus thus is red in color as opposed to clot which is brownish black due to fibrin formation heart vessels and brain vessels are often damaged and result in coronary thrombosis and cerebral thrombosis respectively venous thrombosis sometimes results following surgical operations arterial thrombosis does serious damage to health depending on where it occurs whereas venous thrombosis is not so serious
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