Functions of Hb:
1. Transport of oxygen and carbon dioxide .(For detail see function of RBC)
2.Maintenance of PH
3. Maintenance of ionic balance
4.Formation of pigments of bile (bilirubin biliverdin) stool (stercobilin)and urine (urobilinogen)
DISORDERS OF Hb AND RBC
Haemolysis:
Liberation of Hb in plasma as a result of RBC breakdown is called haemolysis cases which lead to haemolysis are as follows:
1. Haemolysis occurs when fat solvents like ether chloroform benzene etc dissolve the RBC membrane (made up of fatty acids) and liberate Hb from the cell
2. Osmosis : Distilled water and hypotonic saline penetrate in the RBCs increase their volume and consequently the RBCs burst setting the Hb free
3. Surface tension : Bile salts and saponins lower the surface tension and bring about lysis of the RBC
4. Physical: Freezing and thawing of blood alternately break up the RBC
5.Mechanical: Shaking and stiring the blood vigorously result in the lysis of the blood
6. Drugs: Quinine nitrite phenacetin etc may produce haemolysis
7. Haemolytic Toxins of bacterial cultures of steptococcus haemolyticus can cause haemolysis
8. viper venom : the venom of viper snake causes death by haemolysis of the RBC
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