Functions of Spleen::
1. Formation of blood cells:: (a) RBCs are formed by the spleen only in foetal life After birth it creates RBCs only in severe emergency (b) Lymphocytes are produced by Maiphighian corpuscles of the spleen (c) Spleen develops monocytes to circulate in the blood for defence (d) Spleen also forms platelets
2. store house of Blood :: Spleen is a great reservoir of blood .Blood is poured out from the spleen in circulation at the time of stress anoxia haemorrhage coal gas or co gas poisoning etc Adrenaline injection contracts the spleen and squeezes out the stored blood into circulation
3. Destruction of blood :: Old grown out RBC and WBC are destroyed by RES of the splenic pulp the haemoglobin liberated from the destroyed RBC is broken down to produce bilirubin pigment which is partly oxidised to biliverdin on its way to liver via splenic vein
in some of the abnormal spleens toxic haemolysin is developed which produces a fatal haemolytic anaemia this abnormality is cured if spleen is surgically removed in time perhaps such a spleen may take up the work of destroying not only old but new RBCs also by manufacturing the haemolytic toxins against the RBCs 
4.storage and Transfer of pigments:: Billirubin formed in the spleen is transferred to liver via splenic vein as a component of the juice the separated out iron is slowly transferred via RES cells to bone marrow and liver this is an economical cycle process
5. Spleen the Defence Commander::(a) Immune bodies are formed by the RES of the spleen (b) Foreign particles toxins parasites bacteria and debris are all trapped by RES of the spleen (c) Lymphoid cells react against infection
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