ACTION OF ANGIOTENSION II:
Angiotensin II produces three major effects:
(a) Rapid pressure response due to altered peripheral resistance
(b) Slow pressure response due to altered renal function
(c) Vascular and cardiac hypertrophy and remodelling due to altered cardiovascular structure
Altered peripheral resistance occurs due to direct vasoconstriction enhancement of peripheral noradenergic neurotransmission increase in sympathetic discharge and release of catecholamines from adrenal medulla all these actions lead to rapid rise in blood pressure
Angiotensin II produces increase in Na+ reabsorption in proximal tubule release of aldosterone from adrenal cortex constriction of renal blood vessels and increase in sympathetic tone All these effects produce a slow and sustained rise in blood pressure
Besides above mentioned hemodynamic effects angiotensin II produces increase in production of growth factors any synthesis of extracellular matrix these actions cause alteration in cardiovascular alterations and thereby cardiac remodelling there is hyperplasia and hypertrophy being produced by angiotensin II and this causes muscular hypertrophy also All the actions of angiotensin II are mediated through AT1 receptors
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