G-PROTEINS :: There is a well organized hierarchy in the effect of a drug produced in…
Direct regulation of ionic permeability :: This is the fastest type of receptor -medi…
RECEPTOR EFFECTOR LINKAGE :: Although drug receptor interactions explain clearly the …
pAx and pD2 scale :: It is the pharmacological scale used to express drug antagonism …
NON-COMPETITIVE ANTAGONISM :: If the brinding of the anatagonist is irreversible or n…
DRUG -ANTAGONISM :: It is a type of drug interaction in which the effect of one drug …
DOSE RESPONSE RELATIONSHIP :: The exact relationship between the dose and the respons…
AFFINITY AND INTRINSIC ACTIVITY :: A drug combines with the receptor and many initiat…
TARGETS OF DRUG ACTION :: A drug may act at different sites It may act at the point o…
PHYSIOLOGICAL ACTIONS :: (A) Stimulation :: Certain drugs increase the activity of s…
CHEMICAL PROPERTIES :: (a) Neutralization :: Substances like aluminium hydroxide neut…
MODE OF ACTION OF DRUGS :: A drug can act by virtue of its various properties like ph…
IMPORTANCE OF STRUCTURE ACTIVITY RELATIONSHIP With a change in the chemical constitu…
STRUCTURE - ACTIVITY RELATIONSHIP :: Just as histological structure of an organ is ge…
PHARMACODYNAMICS :: Pharmacodynamics is the branch of pharmacology which describes an…
EXTRACORPOREAL DIALYSIS :: Dialysis is based upon the fact that colloidal particles d…
LUNGS :: General anaesthetics like chloroform ether nitrous oxide etc are excreted th…
Tubular reabsorption :: The drugs may be filtered by glomerular filtration but may no…
EXCRETION OF DRUGS Drugs are excreted either unchanged or as metabolites Generally mo…
Conjugation of drugs :: Conjugation is the biochemical synthesis in which there is ad…
Reduction of drugs :: The halogenated and nitrated aromatic compounds are reduced by …
VARIOUS ROUTES OF BIOTRANSFORMATION OF DRUGS Oxidation of drugs :: This is the most …
CYP 1A:: Two major isoforms are grouped in family 1A Ironically 1A1 was one of the fi…
LISTED INORDER OF APPROXIMATE AMOUNTS OF EACH ISOFORM IN HUMAN LIVER . CYP 3A:: The 3…
DESIGNATIONS FOR HEPATIC ISOFORMS ACTIVE IN DRUG METABOLISM :: In its simplest form t…
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