Conjugation of drugs ::
Conjugation is the biochemical synthesis in which there is addition of molecules of groups of endogenous origin to the functional group of drugs Endogenous molecules may be sulphate glucuronate methyl acetyl glycine etc The functional group of drugs which form conjugates are hydroxyl thio amino etc
Conjugation of drugs ::
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Conjugation Functional Conjugate Examples
reaction groups of drugs Endogenous
conjugated Substance
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Glucuronide --OH; -COOH Glucuronic Salicylic acid
Conjugation --NH2- S acid Disulfarm
Diazepam
Sulfate ester --OH;--NH2 Sulfate Estrone
formation Methyldopa
Methylation --OH;-NH2;-S Methyl group Noradrenaline
Histamine
Peptide formation --COOH Glycine Nicotinic acid
Taurine
Acetylation ---NH2;SO2NH2 Acetyl group Isoniazid
--NH2 NH2 Sulfonamides
Glutathion- --F CI Br Glutathion Ethacrinic acid
combination Bromobenzene
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