PHARMACOLOGY

FACTORS AFFECTING ABSORPTION OF DRUG ::

(A) Factors affecting dissolution rate -high temperature viscosity of solvent solubility of drug esterification binders pressure on tablet etc 

(b) Particle size 

(c) Lipid solubility 

(d) pH and pKa 

(e) Partition coefficient 

(f) Area of absorbing surface 

(g) Blood supply to area of absorption 

(h) Functional state of gastro -intestinal tract 

Factors affecting distribution of drugs ::

(a) Plasma vs tissue pH 

(b) Protein binding capacity of drug 

(c) Ability of drug to cross Blood - brain -barrier and placental barrier 

(d) Tissue binding of drug 

(e) Lipid solubility of drug 

(f) Serum albumin concentration 

Factors affecting metabolism of drugs ::

(a) Condition of liver 

(b) Genetic differences for enzymes 

(c) Enzyme induction and inhibition 

(d) Dose and frequency of drug administration 

Factors affecting excretion of drugs ::

(a) Condition of kidney (renal function) 

(b)  pH of urine 

(c) Tubular secretion 

(d) Excretion of drugs by other routes