SOME EXAMPLES OF ION - CHANNELS AS DRUG TARGETS ::
Ion channel Blockers Modulators
Sodium
- Voltage gated Local anaesthetics Veratridine
- Renal Tubule gated Amiloride Aldosterone
Calcium
Voltage gated Verapamil
Diltiazem
Amlodipine
Potassium
Voltage gated 4-aminopyridine Neuromodulators
ATP sensitive ATP Cromakalim
Sulfonylurea Pinacidil
Chloride
GABA gated Picrotoxin Benzodiazepines
Glutamale gated Ketamine Glycine
Mg2+
Dizocilpine
Similarly many enzymes are direct drug targets Often the drug molecule is a substrate analogue that acts as a competitive inhibitor of the enzyme either binding reversibly e.g. physostigmine for acetylcholinesterase or irreversibily e.g. aspirin for cyclooxygenase
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