Some examples of Enzymes as Drug Targets ::
Name of the Enzyme Inhibitors
Acetylcholinesterase Neostigmine Soman Serin
Cyclo-oxygenase Aspirin Ibuprofen
Angiotensin Converting Enzyme Enalapril Lisinopril
HMG-CO A reductase Atorvastatin Simvastatin
Carbonic anhydrase Acetazolamide
Monoamine oxidase-A Iproniazide
Monoamine oxidase -B Selegiline
Dihydrofolate reductase Trimethoprim Methotrexate
DNA polymerase Cytarabin
Thymidine Kinase Acyclovir
HIV protease Sanquinavir
Reverse transcriptase Zidoxndine
Some drugs inhibit synthesis of endogenous substance (neurotrasmitter ) by inhibiting a particular enzyme and act as false substrate or neurotransmitter e.g.hemicholinium inhibiting choline acetyltransferase carbidopa inhibiting dopa decarboxylase
Carrier molecules as drug targets ::
Sometimes carriers are the target for drugs For example noradrenaline uptake carriers are inhibited by cocaine or reserpine loop diuretics inhibit Na+/K+/Cl- co-transportes cardiac glycosides inhibit Na+k+ATPase omeprazole inhibits H+K+ ATPase ciclosporin inhibits immunophilins taxols inhibit tubulin More number of such carriers are being identified as drug targets
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