PHARMACOKINETICS ::
Most antidepressants are absorbed from gastrointestinal tract when given orally Tricyclic antidepressants are bound to plasma proteins (70-25%) Tricyclic antidepressants are metabolized in liver and many of the metabolites are active They are excreted in urine
Therapeutic Uses ::
(a) Depression of various types
(b) Noctural enuresis
(c) Chronic pain
(d) Catalepsy associated with narcolepsy
(e) Obsessive compulsive phobic states school phobia and attention deficit disorder in children
Adverse effects of antidepressants ::
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Types Minor Major
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Sedation Lassitude Fatigue Sleeplessness Impaired consciousness with alcohol and the drugs
Psychiatric Confusion Aggravation of psychosis agitation
Neurologic Tremors paresthesias Seizures Neuropathy
EEG alterations
Antimuscarinic Blurred vision Constipation Aggravation of Glaucoma
Urinary hesitancy Fuzzy thinking Paralytic ileus Delirium retension of urine
Cardiovascular Orthostatic hypotension ECG Arrhythmias Cardiomyopathy
abnormalities
Others Weight gain Sexual disturbances Gynaecomastia Jaundice
Tremors Sweating Haemolytic anaemia
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