MITOTANE
MITOTANE :: It is o-p- dichloro -diphenyl-dichloroethane It inhibits adrenocorticoste…
MISCELLANEOUS AGENTS
MISCELLANEOUS AGENTS :: Cisplatin : It is diaminodichloro -platinum it enters the ce…
RADIOACTIVE IODINE (I131)
RADIOACTIVE IODINE (I131) :: It is obtained as a fission product of uranium it can a…
RADIOACTIVE SUBSTANCES
RADIOACTIVE SUBSTANCES :: These are the isotopes of various elements which act becau…
AROMATASE INHIBITORS (EXEMESTANE)
AROMATASE INHIBITORS (EXEMESTANE) :: MECHANISM OF ACTION :: Breast cancer cell growt…
PROGESTINS ::
PROGESTINS :: The unopposed prolonged stimulation by estrogens can cause endometraia…
L-ASPARGINASE
L-ASPARGINASE :: It is an enzyme that catalyzes hydrolysis of aspargine to aspartic a…
MITHRAMYCIN (PLICAMYCIN)
MITHRAMYCIN (PLICAMYCIN) :: It interferes with RNA synthesis It is highly toxic and …
ANTICANCER ANTIBIOTICS
ANTICANCER ANTIBIOTICS :: These are cytotoxic agents . Actinomycin-D or Dactinomycin…
EPIPODOPHYLLOTOXINS (ETOPOSIDE AND TENIPOSIDE)
EPIPODOPHYLLOTOXINS (ETOPOSIDE AND TENIPOSIDE) :: Etoposide and Teniposide are natur…
NATURAL PRODUCTS
NATURAL PRODUCTS :: Vinca alkaloids (Vincristine and Vinblastine) :: These agents bi…
METHOTREXATE
METHOTREXATE :: It is the folic acid antagonist and one of the most widely used antim…
MECHANISM OF ACTION OF PYRIMIDINE ANALOGUES
MECHANISM OF ACTION OF PYRIMIDINE ANALOGUES :: Fluorouracil as such is inactive but…
PHARMACOLOGICAL ACTIONS AND PHARMACOKINETICS
PHARMACOLOGICAL ACTIONS AND PHARMACOKINETICS :: Fludarabin another purine analogue i…
VIDARABINE
VIDARABINE :: Vidarabine (arabinosyladenine or Ara A) is adenosine analogue and it i…
ANTI METABOLITES
ANTI METABOLITES :: PURINE ANALOGUES :: These are the agents that affect synthesis o…
ALKYLATION AND CROSS LINKING OF DNA BY A NITROGEN MUSTARD (BIS (CHLOROETHYL) AMINE)
ALKYLATION AND CROSS LINKING OF DNA BY A NITROGEN MUSTARD (BIS (CHLOROETHYL) AMINE) …
PHARMACOLOGICAL ACTIONS AND ADVERSE EFFECTS
PHARMACOLOGICAL ACTIONS AND ADVERSE EFFECTS :: Alkylatling agents interfere with cell…
ALKYLATING AGENTS
ALKYLATING AGENTS :: Mechanism of Action :: As the name suggest these agents are cap…
NATURAL PRODUCTS
NATURAL PRODUCTS :: 1.Vinca alkaloids eg Vincristine Vinblastine Vindesine Navelbine…
CLASSIFICATION OF ANTICANCER DRUGS
CLASSIFICATION OF ANTICANCER DRUGS :: (A) Alkylating agents :: 1.Nitrogen mustards e…
TREATMENT OF CANCER
TREATMENT OF CANCER :: Cancer once diagnosed should ideally be removed in total Each…
COMMON TERMINOLOGY FOR TUMORS IN THE MAJOR TISSUE TYPES
COMMON TERMINOLOGY FOR TUMORS IN THE MAJOR TISSUE TYPES :: Phase wherein there occur…
GENESIS OF CANCER
GENESIS OF CANCER :: Cytotoxic drugs follow the first order reaction they destroy a …
GENERAL PRINCIPLES OF ACTION OF ANTICANCER DRUGS ::
GENERAL PRINCIPLES OF ACTION OF ANTICANCER DRUGS :: Chemotherapy of cancer is diffic…
ONCOGENES
ONCOGENES :: Oncogenes are those genes that confer malignancy on a cell Proto oncogen…
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